html,body,div{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}h1,h2,h3,h4,h5,h6{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;font-weight:bold;}a,p,ul,ol,li,img,span,strong,em{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}table,tbody,tfoot,thead,tr,th,td{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}applet,object,iframe,blockquote,pre,abbr,acronym,address,big,cite,code,del,dfn,font,ins,kbd,q,s,samp,small,strike,sub,sup,tt,var,b,u,i,center,dl,dt,dd,caption,fieldset,form,label,legend{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}article,aside,figure,footer,header,hgroup,section{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}canvas,details,embed,figcaption,menu,nav,output,ruby,summary,time,mark,audio,video{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;font:inherit;}article,aside,details,figcaption,figure,footer,header,hgroup,menu,nav,section{display:block;}body{line-height:1;}b,strong{font-weight:bold;}em,i{font-style:italic;}ol,ul{list-style:none;}blockquote,q{quotes:none;}blockquote:before,blockquote:after,q:before,q:after{content:'';content:none;}:focus{outline:0;}ins{text-decoration:none;}del{text-decoration:line-through;}table{border-collapse:collapse;border-spacing:0;}
.grid-1,.grid-2,.grid-3,.grid-4,.grid-5,.grid-6,.grid-7,.grid-8,.grid-9,.grid-10,.grid-11,.grid-12,.grid-13,.grid-14,.grid-15,.grid-16,.grid-17,.grid-18,.grid-19,.grid-20,.grid-21,.grid-22,.grid-23,.grid-24{position:relative;margin-left:10px;margin-right:10px;}.container-12 .block .omega-grid,.container-16 .block .omega-grid,.container-24 .block .omega-grid{position:relative;margin-left:-10px;margin-right:-10px;}
.clearfix:after{font-size:0;}#skip-link{left:50%;margin-left:-5.25em;margin-top:0;position:absolute;width:auto;z-index:50;}#skip-link a,#skip-link a:link,#skip-link a:visited{background:#444;background:rgba(0,0,0,0.6);color:#fff;display:block;padding:1px 10px 2px 10px;text-decoration:none;-khtml-border-radius:0 0 10px 10px;-moz-border-radius:0 0 10px 10px;-o-border-radius:0 0 10px 10px;-webkit-border-top-left-radius:0;-webkit-border-top-right-radius:0;-webkit-border-bottom-left-radius:10px;-webkit-border-bottom-right-radius:10px;border-radius:0 0 10px 10px;}#skip-link a:hover,#skip-link a:active,#skip-link a:focus{outline:0;}.inline li,.tabs li,.breadcrumb li{list-style:none;display:inline;margin-right:0.5em;}.item-list li{list-style:none;}.pager li{display:inline;margin-right:0.25em;}img{vertical-align:bottom;}.field-label-inline .field-label,.field-label-inline .field-items,.field-label-inline .field-item{display:inline;}
::-moz-focus-inner{border:0;padding:0;}input[type="search"]::-webkit-search-decoration{display:none;}input,button,select,textarea{margin:0;vertical-align:middle;}button,input[type="reset"],input[type="submit"],input[type="button"]{-webkit-appearance:none;-moz-border-radius:11px;-webkit-border-radius:11px;-moz-background-clip:padding;-webkit-background-clip:padding;background-clip:padding-box;border-radius:11px;background:#ddd url(http://d3gz45kfcn01zz.cloudfront.net/sites/all/themes/contrib/omega/omega/images/button.png) repeat-x;background:-webkit-gradient(linear,left top,left bottom,color-stop(0,#fff),color-stop(1,#ddd));background:-moz-linear-gradient(top center,#fff 0%,#ddd 100%);border:1px solid;border-color:#ddd #bbb #999;cursor:pointer;color:#333;font:bold 12px/1.2 Arial,sans-serif;outline:0;overflow:visible;padding:3px 10px 4px;text-shadow:#fff 0 1px 1px;width:auto;*padding-top:2px;*padding-bottom:0px;}button{*padding-top:1px;*padding-bottom:1px;}textarea,select,input[type="date"],input[type="datetime"],input[type="datetime-local"],input[type="email"],input[type="month"],input[type="number"],input[type="password"],input[type="search"],input[type="tel"],input[type="text"],input[type="time"],input[type="url"],input[type="week"]{-webkit-appearance:none;-moz-border-radius:0;-webkit-border-radius:0;border-radius:0;-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box;-moz-background-clip:padding;-webkit-background-clip:padding;background-clip:padding-box;background-color:#fff;border:1px solid;border-color:#848484 #c1c1c1 #e1e1e1;color:#000;outline:0;padding:2px 3px;font-size:13px;font-family:Arial,sans-serif;height:1.8em;*padding-top:2px;*padding-bottom:1px;*height:auto;}input.placeholder_text,textarea.placeholder_text,input:-moz-placeholder,textarea:-moz-placeholder{color:#888;}::-webkit-input-placeholder{color:#888;}button:focus,button:active,input:focus,input:active,select:focus,select:active,textarea:focus,textarea:active{-moz-box-shadow:#06f 0 0 7px;-webkit-box-shadow:#06f 0 0 7px;box-shadow:#06f 0 0 7px;z-index:1;}input[type="file"]:focus,input[type="file"]:active,input[type="radio"]:focus,input[type="radio"]:active,input[type="checkbox"]:focus,input[type="checkbox"]:active{-moz-box-shadow:none;-webkit-box-shadow:none;box-shadow:none;}select[disabled],textarea[disabled],input[type="date"][disabled],input[type="datetime"][disabled],input[type="datetime-local"][disabled],input[type="email"][disabled],input[type="month"][disabled],input[type="number"][disabled],input[type="password"][disabled],input[type="search"][disabled],input[type="tel"][disabled],input[type="text"][disabled],input[type="time"][disabled],input[type="url"][disabled],input[type="week"][disabled]{background-color:#eee;}button[disabled],input[disabled],select[disabled],select[disabled] option,select[disabled] optgroup,textarea[disabled]{-moz-box-shadow:none;-webkit-box-shadow:none;box-shadow:none;-webkit-user-select:none;-moz-user-select:none;user-select:none;color:#888;cursor:default;}textarea,select[size],select[multiple]{height:auto;}@media (-webkit-min-device-pixel-ratio:0){select{background-image:url(http://d3gz45kfcn01zz.cloudfront.net/sites/all/themes/contrib/omega/omega/images/select-arrow.gif);background-repeat:no-repeat;background-position:right center;padding-right:20px;}select[size],select[multiple]{background-image:none;padding:0;}}textarea{min-height:40px;overflow:auto;resize:vertical;width:100%;}optgroup{color:#000;font-style:normal;font-weight:normal;}.ie6-button,* html button{background:#ddd url(http://d3gz45kfcn01zz.cloudfront.net/sites/all/themes/contrib/omega/omega/images/button.png) repeat-x;border:1px solid;border-color:#ddd #bbb #999;cursor:pointer;color:#333;font:bold 12px/1.2 Arial,sans-serif;padding:2px 10px 0px;overflow:visible;width:auto;}* html button{padding-top:1px;padding-bottom:1px;}.ie6-input,* html textarea,* html select{background:#fff;border:1px solid;border-color:#848484 #c1c1c1 #e1e1e1;color:#000;padding:2px 3px 1px;font-size:13px;font-family:Arial,sans-serif;vertical-align:top;}* html select{margin-top:1px;}.placeholder_text,.ie6-input-disabled,.ie6-button-disabled{color:#888;}.ie6-input-disabled{background:#eee;}
body{font:13px/1.5 Verdana,Helvetica,Arial,sans-serif;}a:link,a:visited{color:#0062A0;text-decoration:underline;}a:hover{color:#202124;text-decoration:none;}a:active{color:#202124;text-decoration:none;color:#000;}hr{margin:0;padding:0;border:none;height:1px;background:#5294c1;}h1,h2,h3,h4,h5,h6{letter-spacing:-0.05em;font-family:Georgia,'Times New Roman',serif;}h1{font-size:36px;}h2{font-size:28px;}h1.site-name,h2.site-name{font-size:36px;}h2.block-title{font-size:18px;margin:0;}h2.node-title{font-size:28px;}h3{font-size:21px;}h4{font-size:19px;}h5{font-size:17px;}h6{font-size:15px;}ol{list-style:decimal;}ul{list-style:disc;}ul ul,ol ol{padding-top:0.5em;}.node ol,.node ul{padding-left:1.2em;}.node ul.inline,.node ol.inline{padding-left:0;}p,dl,hr,h1,h2,h3,h4,h5,h6,ol,ul,pre,table,address,fieldset{margin-bottom:20px;}dt,.admin h3{font-size:18px;margin:0;}dd{padding-left:10px;font-size:0.9em;font-style:italic;margin-bottom:20px;}
.logo-img{float:left;margin-right:20px;}.site-name-slogan{float:left;}.site-name{margin-top:20px;}.site-name a{text-decoration:none;}.site-name,.site-slogan{margin-bottom:0;line-height:1em;}.site-slogan{font-weight:normal;}
.menu{margin:0;padding:0;}.menu li{list-style:none;}
.form-actions input{margin-right:0.5em;}.form-actions input:hover{background:#FFFFFF;}label{font-weight:bold;}
.highwire-markup ul{padding-left:40px;}.highwire-markup .contributors{text-align:left;}.highwire-markup div.contributors ol.contributor-list{font-weight:bold;list-style:none;margin:15px 0 0 0;padding:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol.contributor-list li{display:inline;line-height:1.1em;padding:0;margin:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol li a{border:0;font-weight:normal;text-decoration:none;vertical-align:.2em;}.highwire-markup .affiliation-list-reveal{margin-top:10px;}.highwire-markup .affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.highwire-markup .affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.highwire-markup div.contributors ol.affiliation-list{font-weight:normal;list-style:none;}.highwire-markup .hideaffil{left:-9999px;position:absolute;width:5000px;}.highwire-markup div.contributors ol.affiliation-list li{display:list-item;margin-left:5px;padding-left:0;}.highwire-markup div.contributors ol.affiliation-list li address{border:0;display:inline;font-style:italic;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list{list-style:none;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list li{margin-left:0;}.highwire-markup div.contributors li.corresp a{font-weight:normal;text-decoration:none;vertical-align:0em;}.highwire-markup .rev-xref-ref,.highwire-markup .rev-xref{font-family:"Lucida Sans Unicode",Arial,"Lucida Grande",Tahoma,Verdana,Helvetica,sans-serif;}.highwire-markup .corresp-list .corresp-label{font-size:0.85em;line-height:0;vertical-align:super;}.highwire-markup #content-block-markup ul.history-list{list-style-type:none;margin:5px 0;padding:0 0 0;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .article div.section h2{border:0;border-bottom:2px dotted #999;font-size:125%;margin:10px 0 10px 0;}.highwire-markup a.xref-bibr,.highwire-markup a.xref-fig,.highwire-markup a.xref-table{font-weight:bold;text-decoration:none;}.highwire-markup .article div.section h3,.highwire-markup .article div.section h4{display:inline;font-size:1.1em;font-weight:bold;padding:0;margin:0;margin-right:5px;text-transform:none;}.highwire-markup .article div.section h3{padding-bottom:10px;}.highwire-markup .article div.section h4{font-style:italic;}.highwire-markup ul.kwd-group{border-top:1px dotted #999;border-bottom:1px dotted #999;font-size:.833em;font-weight:bold;line-height:2;padding:.5em;margin:0;margin-bottom:1em;text-align:center;}.highwire-markup ul.kwd-group li.kwd{background-color:#d8d8d8;display:inline;padding:.5em;margin:0 .7em;line-height:2;white-space:normal;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .section .list-simple li{list-style:none;}.highwire-markup div.article .fig,.highwire-markup div.article .table{margin:1em 20px 1em 20px;clear:both;}.highwire-markup .fig-inline,.highwire-markup .table-inline{font-size:.85em;text-align:center;}.highwire-markup .fig-inline,.highwire-markup .table-inline{font-size:.85em;border:1px dotted #999;background-color:white;height:auto;padding:1em;margin:1em 10px;text-align:center;float:left;}.highwire-markup div.fig a.in-nw-vis{display:inline;}.highwire-markup .fig-caption,.highwire-markup .table-caption{background-color:#EEE;padding:.25em 1em;border-top:1px solid #CCC;border-left:1px solid #CCC;border-bottom:1px solid #AAA;border-right:1px solid #AAA;padding-top:1em;}.highwire-markup .fig-caption p,.highwire-markup .table-caption p,.highwire-markup .fig-caption span,.highwire-markup .table-caption span{line-height:1.4em;font-weight:bolder;}.highwire-markup .fig-label,.highwire-markup .table-label{font-weight:bold;}.highwire-markup .figure-callout{margin-bottom:0.6em;text-align:center;}.highwire-markup .figure-callout-links a{background:#F5F5F5;border:1px solid #DDD;-moz-border-radius:4px;-webkit-border-radius:4px;border-radius:4px;display:inline-block;font-size:0.85em;padding:0.5em;}.highwire-markup .figure-callout-links a:hover{background:#FCFCFC;}.highwire-markup .figure-callout-links span{display:inline-block;height:20px;line-height:20px;vertical-align:middle;}.highwire-markup .figure-callout-icon{height:20px;margin-right:5px;vertical-align:middle;width:20px;}#colorbox #cboxTitle{background:rgba(83,83,83,0.9);color:#FFF;}.highwire-markup div.caption-clear{clear:both;}.highwire-markup ul.copyright-statement{list-style-type:none;}.highwire-markup div.fn-group ul{list-style:none;margin:0;padding:0;padding-top:5px;}.highwire-markup div.bio{margin-top:1em;}.highwire-markup div.fn-group ul li{border-bottom:1px solid #C8C8C8;margin:0 auto;padding:.5em 0;text-align:left;width:95%;}.highwire-markup div.fn-group ul li p{margin-bottom:0;}.highwire-markup #content-block-markup div.fn-group ul li p{margin:.5em 0;padding:0;}.highwire-markup ol.ref-use-labels{list-style:none;margin-left:.5em;}.highwire-markup ol.cit-list{font-size:0.9em;margin-left:2.5em;padding-left:0;}.highwire-markup ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-list .rev-xref-ref,.highwire-markup div.ref-list .rev-xref-ref:link{border:0;text-decoration:none;}.highwire-markup div.ref-cit,.highwire-markup .ref-cit div,.highwire-markup .ref-cit cite,.highwire-markup .ref-cit ol,.highwire-markup .ref-cit li,.ui-cluetip-content div.ref-cit,.ui-cluetip-content .ref-cit div,.ui-cluetip-content .ref-cit cite,.ui-cluetip-content .ref-cit ol,.ui-cluetip-content .ref-cit li{display:inline;margin-left:0;margin-right:0;padding-left:0;padding-right:0;}.highwire-markup div.ref-cit .cit-metadata li,.ui-cluetip-content div.ref-cit .cit-metadata li{display:inline;}.highwire-markup ol.cit-list li,.ui-cluetip-content ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-cit cite,.ui-cluetip-content div.ref-cit cite{font-style:normal;}.highwire-markup div.ref-cit .cit-vol,.ui-cluetip-content div.ref-cit .cit-vol{font-weight:bolder;}.highwire-markup div.ref-cit div.cit-extra a,.ui-cluetip-content div.ref-cit div.cit-extra a{display:inline-block;font-size:88%;margin-left:0.75em;text-decoration:underline;vertical-align:middle;white-space:nowrap;}.highwire-markup div.ref-cit cite span.cit-source,.highwire-markup div.ref-cit cite abbr.cit-jnl-abbrev,.ui-cluetip-content div.ref-cit cite span.cit-source,.ui-cluetip-content div.ref-cit cite abbr.cit-jnl-abbrev{margin-right:.1em;font-style:italic;}.affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.hw-article-citation div{font-size:0.9em;}.hw-article-citation div + div{margin-top:10px;}.hw-article-citation .citation-info{padding:0 5px 0 0;}.hw-article-citation .doi,.hw-article-citation .cit-date,.hw-article-citation .page-num{font-weight:bold;}.page-num .first-page + .last-page:before{content:" - ";}.orig-source{text-align:center;}.highwire-markup .issue-toc .toc-citation{margin-bottom:10px;}.highwire-markup .issue-toc ul.toc-section li{list-style-type:none;}.highwire-index-by-author-links ul li{padding:0;}.table-expansion{overflow:auto;width:100%;}.table-expansion table{font-family:monospace;}.table-expansion table thead{font-weight:bold;background-color:whitesmoke;}.table-expansion table th,.table-expansion table td{border:1px solid lightgrey;}.table-center{text-align:center;}sup,sub,.nlm-sup,.nlm-sub{font-size:0.75em;position:relative;bottom:0.5em;}sub,.nlm-sub{bottom:-0.5em;}.cit-ref-sprinkles{margin-left:10px;}ol.duplicate{display:none;}.highwire-markup .sc{font-size:0.85em;text-transform:uppercase;}.highwire-markup .disp-formula-label,.highwire-markup .MathJax_Display{font-size:14px;margin-bottom:10px;}.highwire-markup .disp-formula-label{text-align:right;display:block;}.highwire-markup .disp-formula-label::before{content:'(';}.highwire-markup .disp-formula-label::after{content:')';}
.highwire-markup ul.kwd-group,h2,.embo-main-menu a,.highwire-markup .issue-toc .toc-heading,.page-node .main-content-wrapper .pane-node-field-highwire-article-category,.highwire-citation-jnl-embo-full-citation .highwire-cite-authors,.panel-region-content .panels-ajax-tab .panels-ajax-tab-tab,.page-node .main-content-wrapper div.highwire-markup .article div.section h2,div.highwire-markup .article div.section h3,div.highwire-markup .fig-caption span,.sidebar-right-wrapper .pane-panels-ajax-tab-tabs li a,.view-embo-recent-articles .form-select,.meet-editors-month,.not-front .sidebar-right-wrapper .highwire-citation-formats-links ul.hw-citation-links a,.panels-ajax-tab-container-embo_article_ajax_tabs a,.panel-region-sidebar-right a,.pane-highwire-markup .article .ref-list{font-family:'Open Sans';font-style:normal;font-weight:600;}.highwire-cite-metadata-doi .label{font-family:'Open Sans';font-style:normal;font-weight:700;}.panel-region-content .highwire-markup .issue-toc .toc-citation,.highwire-citation-jnl-embo-full-citation .highwire-cite-metadata,.panel-region-sidebar-right,.article p,.article p a{font-family:'Open Sans';font-style:normal;font-weight:normal;}.panel-region-sidebar-right .highwire-article-citation .highwire-cite-title a{font-family:'Source Sans Pro';font-style:normal;font-weight:300;}.highwire-citation-jnl-embo-full-citation h1#embo-page-title,.highwire-article-citation a .highwire-cite-title,.highwire-article-citation a .highwire-cite-subtitle{font-family:'Source Sans Pro';font-style:normal;font-weight:700;}