Cover: “Seeding and transgenic overexpression of alpha‐synuclein triggers dendritic spine pathology in the neocortex” by Sonja Blumenstock, Jochen Herms and colleagues. The image shows layer V pyramidal neurons (green) and some of their apical dendrites in a mouse neocortex, surrounded by phosphorylated α‐synuclein aggregates (magenta). Seeding preformed α‐synuclein fibrils into the dorsal striatum was used to trigger formation of cortical Lewy‐like inclusions. Following α‐synuclein seeding, dendritic spine loss and dystrophic deformation of dendrites was observed. Additionally, a chronic in vivo study in mice overexpressing human α‐synuclein further highlights the impact of cortical α‐synuclein on synaptic plasticity in a time‐resolved manner and provides a link to the pathophysiology underlying dementia. Scientific image by Sonja
Blumenstock, German Center for Neurodegenerative Diseases / Center for Neuropathology and Prion Research, Munich, Germany.